Chem Biodivers

. 2008 Jun;5(6):1023-33. doi: 10.1002/cbdv.200890082.
Combination of l-muscone by lopsided methylation through enol esters
Hiroyuki Matsuda 1, Shigeru Tanaka, Kenichi Yamamoto, Kenya Ishida
Affiliations extend
PMID: 18618396 DOI: 10.1002/cbdv.200890082
A viable engineered course of l-muscone (1) by uneven methylation, trailed by enolate-catching to produce enol esters as intermediates, was depicted. Strangely, the enol esters can be utilized as substrates for enzymatic optical goal to work on optical immaculateness. Furthermore, a few superb new chiral ligands were found for lopsided methylation of (E)- cyclopentadec-2-enone to create l-muscone with high optical immaculateness.

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